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Catheter Injectable Hydrogel-Based Scaffolds for Tissue Engineering Applications in lung disease.

Tiberiu R Shulimzon¹, Shir Giladi², Meital Zilberman^2,3

¹Interventional Pulmonology Unit, Pulmonary Institute, Sheba Medical Center, Tel Hashomer, Israel.

The Israel Medical Association Journal : IMAJ

|December 31, 2020

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A new gelatin-alginate hydrogel scaffold can be injected via catheter for lung volume reduction and tissue regeneration. This minimally invasive approach offers a promising, cost-effective alternative for treating chronic lung diseases.

Area of Science:

Biomaterials Engineering
Regenerative Medicine
Pulmonary Medicine

Background:

Chronic lung diseases like emphysema and pulmonary fibrosis are a leading cause of global mortality.
Current treatments focus on symptom management, disease slowing, and lung transplantation.
Regenerative medicine offers a potential alternative for lung repair and regeneration.

Purpose of the Study:

To engineer a dual-action platform for lung therapy.
To develop a scaffold for remodeling pulmonary architecture (lung volume reduction).
To create a platform for regenerating lost respiratory tissue.

Main Methods:

Developed a hydrogel scaffold using natural polymers: gelatin and alginate.
Engineered the scaffold for injection through long catheters via a bronchoscope.

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Assessed scaffold properties for lung volume reduction and tissue regeneration capabilities.

Main Results:

The gelatin-alginate hydrogel scaffold demonstrated suitable physical and mechanical properties for dual objectives.
Biocompatibility testing on human fibroblasts and mouse mesenchymal cells showed high viability (>70%) up to 7 days post-injection.
Successful catheter-based delivery of the scaffold was confirmed.

Conclusions:

The catheter-injectable hydrogel scaffold combines tissue engineering with minimally invasive procedures.
This offers an inexpensive and convenient alternative to existing scaffolds for lung tissue engineering.
The novel concept holds potential for broader clinical applications in regenerative medicine.