Related Experiment Video
Updated: Nov 23, 2025

In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids
Published on: November 18, 2022
Effect of Particle Size and Interface Composition on the Lipid Digestion of Droplets Covered with Membrane
Lu Liu1,2, Yue Pan1,2, Xiuxiu Zhang1,2
1Food College, Northeast Agricultural University, No.600 Changjiang Street, Xiangfang District, Harbin 150030, China.
Abstract:
The particle size and fatty acid release of droplets covered with milk fat globule membrane phospholipids with different particle sizes (large/MPL-L; medium/MPL-M; and small/MPL-S) and emulsions with different sources (droplets covered with MPL/MPLs; human milk/HM; and infant formula/IF) were investigated using an infant digestion model. During digestion, droplets exhibited different degrees of aggregation, and the order of the particle size was MPL-L > MPL-M > MPL-S. MPL-M and MPL-S were significantly higher than MPL-L in the release of free fatty acids. No significant difference was observed in the FFA release rate between MPLs and HM. However, the rate was significantly higher than that of IF in the intestinal stage. Compared to IF, a higher content of long-chain polyunsaturated fatty acids and a lower content of saturated fatty acid were observed in MPLs and HM.
Related Concept Videos
Lipid Digestion
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
Lipid Absorption
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
Detergent Purification of Membrane Proteins
Asymmetric Lipid Bilayer

