End-tidal CO₂ and transcutaneous CO₂ : Are we ready to replace arterial CO₂ in awake children?

Arterial blood gas analysis (ABG) is the gold standard test for carbon dioxide measurement. End-tidal PCO₂ (PetCO₂ ) and transcutaneous PCO₂ (PtcCO₂ ) are noninvasive alternative methods.

To examine the use of PetCO₂ and PtcCO₂ as PaCO₂ surrogates in awake children.

A prospective observational study. Consecutive awake children in a stable condition referred to the Sleep Unit of Hospital de Pediatría Dr. J. P. Garrahan with suspected or confirmed sleep-related respiratory disorders requiring ABG were included. PetCO₂ and PtcCO₂ were recorded simultaneously during arterial puncture. PetCO₂ and PtCO₂ values were compared with PaCO₂ . Correlation coefficient and Bland-Altman analysis were applied. The sample size was calculated considering a mean difference ≤3 mmHg as clinically acceptable.

Sixty-eight sample sets were obtained from 67 patients. The median age was 9.11 years (0.23-18.76). During 94.1% of the procedures patients breathed spontaneously, 30% needed multiple punctures and 92% resulted in pain. Median (IQR) PaCO₂ (mmHg) was 36.3 (31.45; 40.90), PetCO₂ 33.0 (29; 39) and PtcCO₂ 38.8 (32.95; 43.32). Correlation and agreement for PaCO₂ /PetCO₂ and PaCO₂ /PtcCO₂ was r = .6 and .9, and media of bias = 2.83 (-9.97; 15.64) and -1.88 (-9.01; 5.24), respectively. Hypercapnia (PaCO₂  > 45.0 mmHg) was present in 8/68 (11.8%) samples. Sensitivity, specificity, positive predictive value and negative predictive value to detect hypercapnia with PetCO₂ was 38%, 98%, 75%, and 92%, respectively, and with PtcCO₂ , 100%, 90%, 57%, and 100%, respectively.

PtcCO₂ showed better agreement with PaCO₂ than PetCO₂ but because of the wide dispersion of values, neither method can replace the gold standard. Transcutaneous CO₂ might be a good screening tool to detect hypercapnia in awake children.