Open tubular ion chromatography: A state-of-the-Art review

This review summarizes the progress in open tubular ion chromatography (OTIC) over the period from 1981 to 2020. Although OTIC columns provide superior column efficiency, require very little sample volumes, and consume a minimum level of eluents compared to regular packed columns, not many reports can be found from the literature mainly due to the difficulties in the preparation of OTIC columns and the harsh system requirements, such as pL-nL injections and extremely small detection volumes. However, technical advances, e.g., capacitively coupled contactless conductivity detectors (C⁴Ds), hydroxide eluent compatible polymer-based OTIC columns, electrodialytic capillary suppressors, and nanovolume gas-free hydroxide eluent generators (EGs), have removed the obstacles to OTIC. As such, in this review, the author focused on the development of the key components in an OTIC system from the perspective of instrument development. A brief revisit of open tubular (OT) column theory is first presented, followed by a discussion of the system configuration and component development. Attention is given to the advances in the development of the suppressed open tubular ion chromatography (SOTIC) system.