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A Method For Production of Recombinant mCD1d Protein in Insect Cells.

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Published on: December 10, 2007

Animal models for human group 1 CD1 protein function.

Emmelie Eckhardt¹, Max Bastian¹

¹Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald - Insel Riems, Germany.

Molecular Immunology

|January 1, 2021

Summary

This summary is machine-generated.

Group 1 CD1 molecules are crucial for T cell responses and antimicrobial immunity across species. Transgenic mouse models have significantly advanced our understanding of CD1-dependent immune functions.

Keywords:

Animal models Group 1 CD1 Lipid antigens T cells

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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

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Published on: February 28, 2019

Area of Science:

Immunology
Cell Biology

Background:

The CD1 antigen presenting system is evolutionarily conserved in vertebrates.
Group 1 CD1 molecules (CD1a, CD1b, CD1c) are recognized by T cells with diverse T cell receptors.
Investigating group 1 CD1 function was challenging due to lack of expression in mice.

Purpose of the Study:

To review animal studies on group 1 CD1 function.
To highlight the mechanistic understanding gained from CD1-restricted T cell responses.
To discuss ongoing and future research directions.

Main Methods:

Review of existing literature on animal models of CD1.
Analysis of studies utilizing group 1 CD1 transgenic mouse models.
Comparative analysis of CD1-dependent immune functions in different species.

Main Results:

Alternative animal models like guinea pigs and cattle have elucidated basic CD1-dependent antimicrobial immunity.
Group 1 CD1 transgenic mouse models have been instrumental in understanding CD1-restricted T cell responses.
These models have provided mechanistic insights into T cell recognition and activation.

Conclusions:

Animal studies, particularly with transgenic mice, are vital for understanding group 1 CD1 function.
CD1-dependent immune responses play a significant role in host defense.
Further research using these models promises deeper insights into immunology.