The freeze-all strategy after IVF: which indications?

Area of Science:

• Reproductive Medicine
• Gynecology
• In Vitro Fertilization

Background:

• The freeze-all strategy involves cryopreserving all embryos, contrasting with conventional fresh embryo transfer.
• Initially a rescue measure for ovarian hyperstimulation syndrome, it's now used to potentially enhance implantation rates.
• Concerns exist regarding its impact on live birth rates and perinatal outcomes in certain infertile populations.

Purpose of the Study:

• To review current research on the freeze-all strategy.
• To identify patient subgroups who may benefit most from this approach.
• To provide guidance for clinicians regarding its application in daily practice.

Main Methods:

• Systematic review of scientific literature.
• Analysis of studies comparing freeze-all strategy with fresh embryo transfer.
• Evaluation of implantation rates, live birth rates, and perinatal outcomes.

Main Results:

• The freeze-all strategy's effectiveness varies across different patient subgroups.
• Evidence suggests potential benefits in specific indications, but not universally.
• Concerns regarding adverse perinatal outcomes require further investigation.

Conclusions:

• The freeze-all strategy is not universally superior to fresh embryo transfer.
• Careful patient selection is crucial to optimize outcomes.
• Further research is needed to clarify its role and address safety concerns.