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Updated: Nov 23, 2025
Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
Published on: August 12, 2015
The role of tumor suppressor short non-coding RNAs on breast cancer
Shokooh Salimimoghadam1, Sina Taefehshokr2, Reid Loveless3
1Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Khouzestan, Iran.
Abstract:
Characterized by remarkable levels of aggression and malignancy, BC remains one of the leading causes of death in females world wide. Accordingly, significant efforts have been made to develop early diagnostic tools, increase treatment efficacy, and improve patient prognosis. Hopefully, many of the molecular mechanisms underlying BC have been detected and show promising targeting potential. In particular, short and long non-coding RNAs (ncRNAs) are a class of endogenous BC controllers and include a number of different species including microRNAs, Piwi-interacting RNAs, small nucleolar RNA, short interfering RNAs, and tRNA-derivatives. In this review, we discuss the tumor suppressing roles of ncRNAs in the context of BC, and the mechanisms by which ncRNAs target tumor hallmarks, including apoptosis, proliferation, invasion, metastasis, epithelial-mesenchymal transition, angiogenesis, and cell cycle progression, in addition to their diagnostic and prognostic significance in cancer treatment.
Insights
Non-coding RNAs (ncRNAs) show tumor-suppressing roles in breast cancer (BC). This review explores how ncRNAs target BC hallmarks and their potential for diagnostics and improved patient prognosis.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Breast cancer (BC) is a major global health concern for women, characterized by high aggression and malignancy.
- Significant research focuses on early diagnostics, treatment efficacy, and patient prognosis for BC.
- Molecular mechanisms of BC are increasingly understood, revealing promising therapeutic targets.
Purpose of the Study:
- To review the tumor-suppressing roles of non-coding RNAs (ncRNAs) in breast cancer.
- To elucidate the mechanisms by which ncRNAs target key cancer hallmarks.
- To highlight the diagnostic and prognostic significance of ncRNAs in BC treatment.
Main Methods:
- Literature review of studies on ncRNAs in breast cancer.
- Analysis of molecular mechanisms targeted by ncRNAs.
- Synthesis of data on diagnostic and prognostic applications of ncRNAs.
Main Results:
- ncRNAs, including microRNAs, Piwi-interacting RNAs, and others, act as endogenous controllers of BC.
- ncRNAs effectively target critical tumor hallmarks such as apoptosis, proliferation, invasion, metastasis, epithelial-mesenchymal transition, angiogenesis, and cell cycle progression.
- ncRNAs demonstrate significant potential as diagnostic and prognostic biomarkers in BC.
Conclusions:
- ncRNAs play a crucial role in suppressing breast cancer development and progression.
- Targeting ncRNAs offers a promising strategy for novel BC therapies.
- ncRNAs hold significant value for improving BC diagnosis and patient outcomes.
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