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Ionic liquids in electrokinetic chromatography.

Raymond B Yu1, Joselito P Quirino1

  • 1Australian Centre for Research on Separation Science (ACROSS), School of Natural Sciences-Chemistry, University of Tasmania, Hobart, Tasmania 7001, Australia.

Journal of Chromatography. A
|January 1, 2021
PubMed
Summary
This summary is machine-generated.

Ionic liquids enhance separations in electrokinetic chromatography (EKC) by acting as additives in separation media. This review covers their use in chiral and achiral separations from 2015-2020.

Keywords:
Capillary electrophoresisChiral separationElectrokinetic chromatographyIonic liquidsStackingSweeping

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Area of Science:

  • Analytical Chemistry
  • Separation Science

Background:

  • Ionic liquids (ILs) are explored as additives to enhance separation media in electrokinetic chromatography (EKC).
  • Recent advancements focus on improving both achiral and chiral separations using ILs.

Purpose of the Study:

  • To critically review the developments in using ionic liquids in various EKC modes from 2015 to mid-2020.
  • To analyze the role of ILs in improving separation efficiency and discuss future research directions.

Main Methods:

  • A comprehensive literature search was conducted using Scopus, identifying 48 relevant research articles.
  • Articles were categorized based on the role of ionic liquids: as sole pseudophases or in conjunction with other pseudophases.

Main Results:

  • Over half of the reviewed studies focused on chiral separations, often utilizing ILs with additional additives or pseudophases.
  • Ionic liquids demonstrated significant improvements in separation performance across different EKC modes.
  • The application of ILs in online sample concentration techniques like field enhancement and sweeping was also briefly examined.

Conclusions:

  • Ionic liquids show great promise for enhancing separation capabilities in electrokinetic chromatography.
  • Further research is recommended to fully explore the potential of ILs in advanced separation techniques and chiral resolutions.