Related Experiment Video

Updated: Nov 23, 2025

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

3.9K

Protection of the Newborn Through Vaccination in Pregnancy

Bahaa Abu-Raya1,2, Kirsten Maertens3

  • 1Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.

Neoreviews
|January 2, 2021
PubMed

Insights

Vaccinating pregnant women protects newborns from serious infections like pertussis and influenza. New vaccines aim to further reduce infant risks from respiratory syncytial virus and group B Streptococcus.

Area of Science:

  • Immunology and Public Health
  • Maternal and Neonatal Health

Background:

  • Newborns and infants are highly susceptible to severe infections from pathogens such as Bordetella pertussis, influenza, respiratory syncytial virus, and group B Streptococcus.
  • A critical window of vulnerability exists in early life, necessitating protective strategies against common infectious agents.

Purpose of the Study:

  • To review currently recommended vaccines administered during pregnancy.
  • To highlight the benefits of maternal vaccination for newborns and infants.
  • To discuss advancements in developing new vaccines targeting infant infections.

Main Methods:

  • Review of existing literature and public health recommendations on vaccines during pregnancy.
  • Analysis of the impact of maternal immunization on infant infectious disease burden.
  • Examination of ongoing research and development in maternal vaccine candidates.

Main Results:

  • Maternal vaccination against diseases like influenza, pertussis, and tetanus has proven successful in reducing infant susceptibility.
  • Emerging vaccines show promise in decreasing the incidence of respiratory syncytial virus and group B Streptococcus infections in infants.

Conclusions:

  • Vaccination during pregnancy is a key strategy to protect vulnerable newborns and infants from severe infections.
  • Continued research and development of maternal vaccines are crucial for further enhancing infant protection against infectious diseases.

More Related Videos

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C07:13

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

19.1K
Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets08:12

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets

Published on: September 6, 2019

7.4K

Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
586
Vaccinations01:51

Vaccinations

Overview
49.4K
Active versus Passive Immunity01:31

Active versus Passive Immunity

Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
9.3K
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
2.4K
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.7K
Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
3.8K