Related Experiment Video
Updated: Nov 23, 2025
07:12
Laminectomy for the Removal of Thoracic Ossification of the Ligamentum Flavum TOLF Using Ultrasonic and Conventional Osteotomes
Published on: April 21, 2023
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Non-coding RNAs in ossification of spinal ligament
Xiaoqiu Yuan1, Lei Shi1, Yu Chen2
1Spine Center, Department of Orthopaedics, Changzheng Hospital, Second Military, Medical University, No. 415 Fengyang Rd, Shanghai, 20003, China.
Summary
Non-coding RNAs (ncRNAs) are involved in spinal ligament ossification. This review explores their role in disease development and potential as clinical biomarkers for ossification of the spinal ligament (OSL).
Area of Science:
- Biochemistry
- Molecular Biology
- Genetics
Background:
- Ossification of the spinal ligament (OSL) involves ectopic ossification of spinal ligament tissues.
- The precise molecular mechanisms underlying OSL pathogenesis remain unclear.
- Non-coding RNAs (ncRNAs) have recently emerged as significant functional players in OSL development.
Purpose of the Study:
- To review and summarize the current understanding of ncRNA deregulation and function in OSL.
- To consolidate knowledge on the role of ncRNAs in the molecular pathogenesis of OSL.
Main Methods:
- A systematic literature search was conducted on PubMed for studies on ncRNAs in OSL.
- Studies were manually selected based on predefined inclusion criteria.
- Included studies focused on high-throughput sequencing, microarray analysis, functional roles, and biomarker potential of ncRNAs.
Main Results:
- 14 studies were reviewed, encompassing ncRNA sequencing/microarrays (4 studies), functional roles (8 studies), and biomarker applications (2 studies).
- ncRNAs are implicated in regulating fibrocyte osteogenesis and inflammation in OSL.
- ncRNAs demonstrate potential as biomarkers for risk prediction and early detection of OSL.
Conclusions:
- ncRNAs play a critical role in the cellular processes of osteogenesis and inflammation within spinal ligament ossification.
- ncRNAs hold significant promise for clinical applications in OSL management, including therapeutic targeting, risk stratification, and early diagnosis.
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