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Studying leukemia stem cell properties and vulnerabilities with human iPSCs.

Nikolaos Spyrou1, Eirini P Papapetrou1

  • 1Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Stem Cell Research
|January 3, 2021
PubMed
Summary

Induced pluripotent stem cells (iPSCs) from acute myeloid leukemia (AML) patients create faithful cancer models. This iPSC modeling reveals non-genetic cancer heterogeneity and leukemia stem cell (LSC) plasticity, offering new therapeutic targets.

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