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Related Concept Videos

Overview of Exosomes01:36

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Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
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Updated: Nov 23, 2025

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Bioengineered Exosomal Extracellular Vesicles in Cancer Therapeutics.

J Miles1, M Andre1, A Caobi1

  • 1Department of Immunology and NanoMedicine, Herbert Wertheim College of Medicine, Florida International University 11200 SW 8th Street Miami, FL 33199, USA.

Critical Reviews in Biomedical Engineering
|January 3, 2021
PubMed
Summary
This summary is machine-generated.

Bioengineered exosomes show promise as nanotherapeutics for various cancers. These engineered extracellular vesicles (EVs) can disrupt cancer progression and overcome therapeutic resistance, offering a targeted treatment approach.

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Area of Science:

  • Oncology
  • Nanotechnology
  • Biochemistry

Background:

  • Liquid biopsies offer a less invasive method for identifying cancer biomarkers, including circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and extracellular vesicles (EVs).
  • Extracellular vesicles, particularly exosomes, play a significant role in cancer progression, metastasis, and therapeutic resistance.
  • Exosomes, the smallest EVs, are increasingly recognized for their potential as nanotherapeutics in oncology.

Purpose of the Study:

  • To review the current literature on the clinical relevance and therapeutic applications of bioengineered exosomes for treating prevalent cancers.
  • To highlight the potential of exosomes as nanotherapeutics to disrupt cancer progression and overcome treatment resistance.

Main Methods:

  • Literature review of studies investigating bioengineered exosomes for cancer therapy.
  • Analysis of research focusing on exosomes derived from or engineered to target specific cancers like melanoma, glioma, breast, pancreatic, hepatic, cervical, prostate, and colon cancers.

Main Results:

  • Bioengineered exosomes demonstrate effectiveness as therapeutic agents against various cancers.
  • Studies indicate that exosomes can be engineered to disrupt cancer progression and potentially overcome therapeutic resistance.
  • Exosomes derived from tumors can promote malignancy and metastasis, underscoring the need for engineered therapeutic approaches.

Conclusions:

  • Bioengineered exosomes represent a promising and effective strategy for targeted cancer therapy.
  • Further research into exosome-based nanotherapeutics could lead to novel treatment modalities for a wide range of cancers.