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Impact of Platelet Count in Retinopathy of Prematurity
Nedime Şahinoğlu Keşkek1, Hande Gülcan2, Gürsel Yılmaz3
1Başkent University Faculty of Medicine, Adana Research and Training Center, Department of Ophthalmology, Adana, Turkey.
Insights
Low platelet count in premature infants is a significant risk factor for developing retinopathy of prematurity (ROP). This finding adds to known risks like low birth weight and gestational age.
Area of Science:
- Neonatal Medicine
- Ophthalmology
Background:
- Retinopathy of prematurity (ROP) is a leading cause of vision impairment in premature infants.
- Established risk factors include low birth weight (BW) and prematurity (gestational age, GA).
Purpose of the Study:
- To investigate risk factors for ROP, with a specific focus on platelet count.
- To identify predictors for severe ROP requiring laser treatment (Type 1 ROP).
Main Methods:
- Retrospective analysis of 137 infants categorized into no ROP, mild ROP, and severe ROP (Type 1).
- Logistic regression analysis was used to evaluate risk factors, including platelet count in the first week post-birth.
Main Results:
- Low platelet count, low BW, and low GA were significant risk factors for ROP development.
- Low platelet count, low BW, low GA, and need for ventilation were associated with progression to Type 1 ROP.
Conclusions:
- Low platelet count in the first week of life is a novel risk factor for ROP.
- Findings reinforce the importance of BW, GA, ventilation, and introduce platelet count as critical factors in ROP management.
Objectives:
The aim of the study was to investigate the risk factors for retinopathy of prematurity (ROP), including platelet count.
Materials And Methods:
This retrospective study analyzed 137 infants in 3 subgroups: no ROP; mild ROP, and severe ROP requiring laser treatment (type 1 ROP). A retrospective review of records was performed and statistical analysis of possible risk factors for ROP including platelet count was evaluated by using logistic regression.
Results:
Birth weight (BW), gestational age (GA), and low platelet count in the first week after birth were significant risk factors for developing ROP (p=0.038, 0.02, and 0.004, respectively). BW, GA, ventilation, and lower platelet count were associated with progression to type 1 ROP (p=0.004; 0.027, and 0.021, respectively).
Conclusion:
Lower platelet count in the first week after birth is a risk factor for ROP development in addition to the previously established factors of ventilation need, low BW, and low GA.
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