Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

7.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
7.2K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.6K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.6K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

5.3K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.3K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.1K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

8.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.7K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

2.4K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapeutic strategies for multi-resistant <i>Escherichia coli</i> in urinary tract infections-a cause for concern.

JAC-antimicrobial resistance·2026
Same author

3D - pored Ixora Coccinea Linn. extracted nanocellulose-curcumin composites for tissue engineering applications.

International journal of biological macromolecules·2025
Same author

Engineering a bacterial polysaccharide-based metal-organic framework-enhanced bioactive 3D hydrogel for accelerated full-thickness wound healing.

Biomaterials science·2025
Same author

Tissue engineered implants derived from sustainable nanocellulose and polyethylene glycol (PEG) loaded with polyphenols: An in vivo study on albino rats for wound dressing.

International journal of biological macromolecules·2025
Same author

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth.

Journal of visualized experiments : JoVE·2024
Same author

Air-jet spun tissue engineering scaffolds incorporated with diamond nanosheets with improved mechanical strength and biocompatibility.

Colloids and surfaces. B, Biointerfaces·2022
Same journal

Barbatolic Acid Prevents Tau and Amylin Interaction and Stimulates the Growth of Acetylated Microtubules in Cell Culture.

Current drug targets·2026
Same journal

Harnessing HIF-1α for Diabetic Wound Healing: From Molecular Insights to Therapeutic Strategies.

Current drug targets·2026
Same journal

Extracellular Vesicles from Mesenchymal Stem Cells Alleviate Spinal Cord Injury via the miR-486-5p/PTEN/PI3K/AKT Pathway.

Current drug targets·2026
Same journal

Improving B-cell Linear Epitope Prediction <i>via</i> Multiple Feature Fusion and an Integrated Machine Learning Algorithm.

Current drug targets·2026
Same journal

Mechanistic Insights into the Inhibition of Plasmodium falciparum DNA Gyrase A by Withanolide Derivatives through Integrated Computational Analysis.

Current drug targets·2026
Same journal

Epitranscriptomics in Breast Cancer: The Unveiled Role of RNA Modifications.

Current drug targets·2026
See all related articles

Related Experiment Video

Updated: Nov 23, 2025

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

8.7K

Natural Products as Anticancer Agents.

Ruby Varghese1, Yogesh B Dalvi1

  • 1Pushpagiri Research Centre, Pushpagiri Institute of Medical Sciences and Research Centre, Tiruvalla, Kerala- 689101, India.

Current Drug Targets
|January 4, 2021
PubMed
Summary
This summary is machine-generated.

Medicinal plants and mushrooms offer natural compounds that combat cancer by inhibiting angiogenesis and metastasis. Research highlights their potential for developing effective cancer therapeutics with fewer side effects.

Keywords:
Angiogenesisapoptosiscancerinflammatory cytokinesmetastasisreactive oxygen species

More Related Videos

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
09:03

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

Published on: January 26, 2024

562
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.3K

Related Experiment Videos

Last Updated: Nov 23, 2025

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

8.7K
Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
09:03

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

Published on: January 26, 2024

562
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.3K

Area of Science:

  • Natural Product Chemistry
  • Oncology
  • Pharmacology

Background:

  • Medicinal plants and mushrooms have historically been used in traditional medicine for their health benefits.
  • There is a growing scientific interest in the pharmaceutical potential of natural products for cancer therapy.
  • Certain plants and mushrooms show promise in combating angiogenesis and cancer metastasis.

Purpose of the Study:

  • To review recent findings on pharmacologically active compounds from plants and mushrooms.
  • To explore their anti-tumor potential and mechanisms against cancer metastasis and angiogenesis.
  • To provide knowledge for developing novel cancer therapeutics with minimal adverse effects.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of bioactive compounds and their mechanisms of action.
  • Focus on natural products targeting cancer metastasis and angiogenesis.

Main Results:

  • Identified key plants (e.g., Catharanthus roseus, Curcuma longa) and mushrooms (e.g., Ganoderma, Trametes versicolor).
  • Highlighted mechanisms including free radical scavenging, apoptosis induction, and inhibition of angiogenesis and metastasis.
  • Confirmed the role of anti-cancer compounds in checking cancer invasion, migration, and proliferation.

Conclusions:

  • Natural products show significant promise in preventing cancer metastasis and angiogenesis.
  • Further investigation into these compounds could lead to the development of safer cancer therapeutics.
  • This is a rapidly advancing research area with substantial potential for clinical application.