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Engineering a bacterial polysaccharide-based metal-organic framework-enhanced bioactive 3D hydrogel for accelerated
Aniruddha Dan1, Ankita Panigrahi2, Hemant Singh1,3,4
1Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar, Gujarat, India. mukesh.d@iitgn.ac.in.
Biomaterials Science
|May 28, 2025
Summary
This study presents a novel hydrogel wound dressing enriched with copper-metal-organic framework (Cu-MOF) and tannic acid. This advanced dressing significantly accelerates full-thickness wound repair in rats by promoting tissue regeneration and exhibiting antibacterial properties.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing Research
Background:
- Hydrogels offer superior biocompatibility and hydration for wound healing compared to traditional dressings.
- Current wound dressings often fail to address complex healing requirements.
- Hydrogels provide a versatile platform for incorporating therapeutic agents for enhanced wound care.
Purpose of the Study:
- To develop a multifunctional hydrogel dressing for effective full-thickness wound repair.
- To investigate the therapeutic potential of a copper-metal-organic framework (Cu-MOF) and tannic acid-enriched hydrogel.
- To evaluate the biocompatibility and wound healing efficacy of the novel hydrogel dressing.
Main Methods:
- Fabrication of a gellan-gum/zein based hydrogel incorporating Cu-MOF and tannic acid.
- Assessment of hydrogel matrix stability through physical interactions (electrostatic, hydrogen bonding).
- In vitro evaluation of antioxidant, antibacterial, hemocompatibility, and cytotoxicity (L929 fibroblast cells).
- In vivo testing on full-thickness rat wound models to assess healing performance.
Main Results:
- The developed hydrogel exhibited stable matrix formation with antioxidant and antibacterial properties.
- The hydrogel dressing demonstrated hemocompatibility and biocompatibility with L929 fibroblast cells.
- Significant acceleration of full-thickness wound healing in rats was observed, with only 1.6% remaining wound area.
- Histopathology confirmed enhanced re-epithelialization, neovascularization, and hair follicle formation.
Conclusions:
- The Cu-MOF and tannic acid-enriched hydrogel dressing is a promising candidate for advanced wound management.
- The hydrogel effectively promotes full-thickness wound repair by facilitating tissue regeneration and providing antimicrobial benefits.
- This multifunctional hydrogel represents a significant advancement over conventional wound dressings, improving clinical outcomes.
