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Related Concept Videos

Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Bacterial Phylum Spirochaetes

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Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
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Staphylococcus pseudintermedius: an undocumented, emerging pathogen in humans.

Suneel Bhooshan1, Vikrant Negi2, Prabhat K Khatri1

  • 1Department of Microbiology Dr. S. N. Medical College, Jodhpur, Rajasthan, India.

GMS Hygiene and Infection Control
|January 4, 2021
PubMed
Summary

Methicillin-resistant Staphylococcus pseudintermedius (MRSP) infections in humans are a growing concern due to similarities with human pathogens. Understanding MRSP transmission and resistance is crucial to prevent it from becoming a global health issue.

Keywords:
Staphylococcus aureusStaphylococcus pseudintermediuszoonosis

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Area of Science:

  • Veterinary Medicine
  • Infectious Diseases
  • Microbiology

Background:

  • Methicillin-resistant Staphylococcus pseudintermedius (MRSP) infections in humans, first recorded in 2006, are increasingly recognized.
  • MRSP shares characteristics with multidrug-resistant Staphylococcus aureus, posing a potential zoonotic threat.
  • The Staphylococcus intermedius group (SIG) includes pathogens with significant public health implications.

Purpose of the Study:

  • To review the current understanding of Staphylococcus pseudintermedius (S. pseudintermedius) infections in humans.
  • To highlight the concerns regarding multidrug resistance and zoonotic potential of S. pseudintermedius.
  • To emphasize the need for accurate identification and further research into S. pseudintermedius pathogenesis.

Main Methods:

  • Literature search using "Staphylococcus pseudintermedius" in PubMed and other databases.
  • Review of existing studies on MRSP in humans and animals.
  • Analysis of reported virulence factors, pathogenicity, and drug resistance.

Main Results:

  • S. pseudintermedius is easily transmitted from animals to humans through close contact.
  • Resistance to beta-lactams, including methicillin, is a primary concern, particularly in developing countries with unregulated antibiotic use.
  • Multidrug-resistant S. pseudintermedius isolates have been reported in clinical specimens from Europe.

Conclusions:

  • Accurate identification of S. pseudintermedius is essential for studying its pathogenesis.
  • Further research is needed to understand the virulence and pathogenicity of S. pseudintermedius.
  • Preventative measures are required to mitigate the risk of S. pseudintermedius becoming a global health problem.