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Published on: February 23, 2014
Staphylococcus pseudintermedius: an undocumented, emerging pathogen in humans
Suneel Bhooshan1, Vikrant Negi2, Prabhat K Khatri1
1Department of Microbiology Dr. S. N. Medical College, Jodhpur, Rajasthan, India.
Abstract:
The first infections of methicillin-resistant Staphylococcus pseudintermedius in humans were recorded in 2006, and is now becoming a concern because of its close similarities to human pathogens in the Staphylococcus intermedius group (SIG). These bacteria have all the properties which a multidrug-resistant Staphylococcus aureus possesses. The literature was searched using the term "Staphylococcus pseudintermedius" in PubMed and other reference databases. The virulence factor and the pathogenicity are under investigation, but reports have suggested that this commensal of animals is transmitted easily via close contact to animals by owners, veterinarians and staff. Resistance to beta-lactams (including methicillin) is a primary concern. Drug resistance to methicillin is a considerable problem in developing countries, as antibiotic use is not regulated. Studies from Europe have reported multidrug resistant isolates from clinical specimens. Although data on drug resistance and pathogenesis of S. pseudintermedius are not sufficient, it is extremely important to identify the pathogen correctly. Only then can its pathogenesis be studied during the course of disease and appropriate measures developed to prevent it becoming a global problem.
Insights
Methicillin-resistant Staphylococcus pseudintermedius (MRSP) infections in humans are a growing concern due to similarities with human pathogens. Understanding MRSP transmission and resistance is crucial to prevent it from becoming a global health issue.
Area of Science:
- Veterinary Medicine
- Infectious Diseases
- Microbiology
Background:
- Methicillin-resistant Staphylococcus pseudintermedius (MRSP) infections in humans, first recorded in 2006, are increasingly recognized.
- MRSP shares characteristics with multidrug-resistant Staphylococcus aureus, posing a potential zoonotic threat.
- The Staphylococcus intermedius group (SIG) includes pathogens with significant public health implications.
Purpose of the Study:
- To review the current understanding of Staphylococcus pseudintermedius (S. pseudintermedius) infections in humans.
- To highlight the concerns regarding multidrug resistance and zoonotic potential of S. pseudintermedius.
- To emphasize the need for accurate identification and further research into S. pseudintermedius pathogenesis.
Main Methods:
- Literature search using "Staphylococcus pseudintermedius" in PubMed and other databases.
- Review of existing studies on MRSP in humans and animals.
- Analysis of reported virulence factors, pathogenicity, and drug resistance.
Main Results:
- S. pseudintermedius is easily transmitted from animals to humans through close contact.
- Resistance to beta-lactams, including methicillin, is a primary concern, particularly in developing countries with unregulated antibiotic use.
- Multidrug-resistant S. pseudintermedius isolates have been reported in clinical specimens from Europe.
Conclusions:
- Accurate identification of S. pseudintermedius is essential for studying its pathogenesis.
- Further research is needed to understand the virulence and pathogenicity of S. pseudintermedius.
- Preventative measures are required to mitigate the risk of S. pseudintermedius becoming a global health problem.
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