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Macular lesions in Alport's disease
American Journal of Ophthalmology
|October 1, 1977
Summary
New retinal lesions were observed in male patients with Alport's disease. These previously undescribed whitish-yellow spots appear in the macular area, even after successful kidney transplantation.
Area of Science:
- Ophthalmology
- Nephrology
- Genetics
Background:
- Alport's disease is a genetic kidney disorder.
- Ocular manifestations are known but variable.
Observation:
- Three male patients with Alport's disease underwent ophthalmoscopy.
- Two patients had received successful kidney transplants.
Findings:
- Bilaterally densely packed, whitish-yellow lesions were observed.
- These lesions were located around and within the macular area.
- The spots were superficially situated in the retina.
Implications:
- These retinal findings represent a novel clinical sign in Alport's disease.
- Further research is needed to understand the pathogenesis and clinical significance of these lesions.
- This discovery may aid in earlier diagnosis and monitoring of Alport's disease.