Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myocardial changes in malignant hyperthermia.

J J Fenoglio, N S Irey

    The American Journal of Pathology
    |October 1, 1977
    PubMed
    Summary

    Malignant hyperthermia causes direct cardiac muscle damage, leading to ventricular arrhythmias. This study reveals cardiac myofiber damage, suggesting it

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dilantin-associated lymphadenopathy. Spectrum of histopathologic patterns.

    The American journal of surgical pathology·1995
    Same author

    Immunologic aspects of rejection.

    Progress in cardiovascular diseases·1990
    Same author

    A morphologic study of Vietnam veterans.

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·1989
    Same author

    Immunohistochemical characterization of fibrin(ogen)-related antigens in human tissues using monoclonal antibodies.

    Laboratory investigation; a journal of technical methods and pathology·1989
    Same author

    Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies.

    Arteriosclerosis (Dallas, Tex.)·1989
    Same author

    Pathology and natural history of human myocarditis.

    Pathology and immunopathology research·1988

    Area of Science:

    • Cardiology
    • Pathology
    • Genetics

    Background:

    • Malignant hyperthermia (MH) is a pharmacogenetic disorder.
    • Skeletal muscle pathology in MH is well-documented.
    • Cardiac complications like ventricular fibrillation are common in MH patients.

    Observation:

    • Necropsy findings in 3 MH patients revealed cardiac contraction bands and myofiberlysis.
    • Ultrastructural analysis showed sarcolemma disruptions associated with myofiber damage.
    • These cardiac findings mirror skeletal muscle pathology in MH.

    Findings:

    • Direct damage to cardiac muscle, not solely hyperkalemia, likely causes ventricular arrhythmias in MH.
    • Myofiber overstretching and lysis are key pathological features in the MH heart.

    Implications:

    • Understanding cardiac pathology is crucial for managing MH-related arrhythmias.
    • This research highlights the direct impact of MH on cardiac integrity.
    • Further investigation into cardiac-specific MH treatments may be warranted.

    Related Experiment Videos