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Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
05:42

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

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Oral potentially malignant disorders: new insights for future treatment

Crisitna Gurizzan1, Luigi Lorini, Paolo Bossi

  • 1Department of Medical and Surgical Specialties, Medical Oncology, Radiological Sciences and Public Health University of Brescia, ASST-Spedali Civili, Brescia, Italy.

Current Opinion in Otolaryngology & Head and Neck Surgery
|January 4, 2021
PubMed
Abstract

Insights

Oral potentially malignant disorders (OPMDs) require better treatments. While surgery is common, new biomarkers and systemic prevention strategies are crucial for reducing malignant transformation and improving patient outcomes.

Area of Science:

  • Oral pathology
  • Oncology
  • Biomarker discovery

Background:

  • Oral potentially malignant disorders (OPMDs) represent a significant clinical challenge.
  • Current treatments, primarily surgery, have limitations in preventing malignant transformation due to high recurrence rates and field cancerization.

Purpose of the Study:

  • To define the challenges associated with OPMDs.
  • To review current treatment modalities for OPMDs.
  • To provide an overview of ongoing clinical trials and future therapeutic opportunities.

Main Methods:

  • Literature review of existing treatments for OPMDs.
  • Analysis of current clinical trials for OPMDs.
  • Evaluation of emerging biomarkers and therapeutic strategies.

Main Results:

  • Surgery is the primary treatment for OPMDs but has limited efficacy in preventing malignant transformation.
  • Combining systemic therapies with surgery shows potential but requires further investigation.
  • Loss of heterozygosity is a key predictive marker, with microRNAs and immune infiltration emerging as novel biomarkers.

Conclusions:

  • Novel biomarkers, including microRNAs and immune infiltration patterns, are crucial for predicting malignant transformation in OPMDs.
  • New systemic prevention strategies are needed, moving beyond previously unsuccessful chemopreventive trials.
  • Understanding immune infiltration and the immune-equilibrium concept may offer new avenues for OPMD prevention.

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