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Updated: Nov 23, 2025

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers
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Aptamer-Functionalized Micro- and Nanocarriers for Controlled Release.

Margarita Vázquez-González1, Itamar Willner1

  • 1Institute of Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

ACS Applied Materials & Interfaces
|January 4, 2021
PubMed
Summary
This summary is machine-generated.

Aptamers (aptamer-ligand complexes) are used to create smart drug delivery systems. These systems release medication only when specific biomarkers are detected, enabling targeted treatment.

Keywords:
SiO2 nanoparticlescarbon dotsmetal−organic framework particlesmicrocapsulesnanomaterialsnanomedicine

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Drug Delivery

Background:

  • Aptamers, which are nucleic acid sequences that bind specific targets, are increasingly used in medicine.
  • Controlled drug release systems are crucial for effective and safe therapies.

Purpose of the Study:

  • To review recent advancements in using aptamers as stimuli-responsive gates for drug-loaded nanocarriers.
  • To explore aptamer-functionalized carriers for targeted and controlled drug release.

Main Methods:

  • Review of literature on aptamer-gated nanocarriers for drug delivery.
  • Discussion of various aptamer-functionalized carrier types (inorganic, MOF, soft materials).
  • Analysis of preparation chemistries and unlocking mechanisms.

Main Results:

  • Aptamer-ligand complex formation triggers the unlocking of nanocarriers in response to biomarkers.
  • Diverse aptamer-functionalized nanocarriers demonstrate potential for controlled release.
  • The review covers various materials and chemistries for aptamer-gated systems.

Conclusions:

  • Aptamer-gated nanocarriers offer a promising approach for targeted and selective drug delivery.
  • These systems function as "sense-and-treat" materials, responding to specific cellular signals.
  • Stimuli-responsive drug carriers hold significant potential for future biomedical applications.