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Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Recent Advances in Nanomicelles Delivery Systems.

Salah M Tawfik1,2, Shavkatjon Azizov1,3, Mohamed R Elmasry1

  • 1Department of Materials Convergence and System Engineering, Changwon National University, Changwon 51140, Korea.

Nanomaterials (Basel, Switzerland)
|January 5, 2021
PubMed
Summary

Nanomicelles offer promising drug delivery solutions. These nanocarriers efficiently entrap drugs and can be designed for targeted release using various stimuli, overcoming key therapeutic challenges.

Keywords:
drug deliveryfluorescence imagingnanomicellesspectroscopystimulus-responsive

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Efficient and selective drug delivery is a major challenge in therapeutic development.
  • Nanomicelles, formed by amphiphilic molecule self-assembly, show promise as drug nanocarriers due to their size, biocompatibility, and drug-loading capacity.

Purpose of the Study:

  • To review emerging nanomicellar designs for targeted and continuous drug delivery.
  • To discuss the properties and principles of stimuli-responsive nanomicelles.
  • To explore future perspectives and challenges in nanomicelle development.

Main Methods:

  • Review of literature on nanomicellar nanocarriers.
  • Analysis of nanomicelle self-assembly principles.
  • Examination of stimuli-responsive mechanisms (pH, temperature, ultrasound, light, redox).

Main Results:

  • Nanomicelles effectively encapsulate lipophilic drugs.
  • Stimuli-responsive designs enable targeted drug release based on specific triggers.
  • Nanomicelle size and shape are determined by core and corona block properties.

Conclusions:

  • Nanomicelles represent a significant advancement in drug delivery systems.
  • Further research is needed to address challenges and optimize nanomicelle applications.
  • Stimuli-responsive nanomicelles offer a pathway to enhanced therapeutic efficacy.