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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
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Coordination of Multiple Cellular Processes by NR5A1/Nr5a1.

Ken-Ichirou Morohashi1, Miki Inoue1, Takashi Baba1

  • 1Division of Biology of Sex Differences, Graduate School of Medical Sciences, and Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan.

Endocrinology and Metabolism (Seoul, Korea)
|January 5, 2021
PubMed
Summary

Nuclear receptor subfamily 5 group A member 1 (NR5A1) is crucial for organ development and cell regulation. New research identifies NR5A1 target genes, linking its role in cell processes to cellular metabolism.

Keywords:
Ad4BPAdrenal glandsCell differentiationCell proliferationGlycolysisGonadsKnockoutNR5A1Steroidogenic factor 1

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Developmental Biology

Background:

  • Knockout mouse studies revealed NR5A1 (SF-1) is essential for gonad and adrenal gland development.
  • NR5A1 influences cell reprogramming, pluripotency, and proliferation, but its regulatory mechanisms are unclear due to limited knowledge of its target genes.

Purpose of the Study:

  • To elucidate the mechanism by which NR5A1 regulates fundamental cellular processes.
  • To identify NR5A1 target genes involved in metabolic and biological processes.

Main Methods:

  • Utilized newly established technologies to identify NR5A1 target genes.
  • Whole genome studies were employed to gather evidence on potential target genes.

Main Results:

  • Identified NR5A1 target genes associated with metabolic and key biological processes.
  • NR5A1 may coordinate cell differentiation, proliferation, and survival with cellular metabolism.

Conclusions:

  • NR5A1 plays a key role in coordinating cellular processes with metabolism.
  • Further whole genome studies are needed to fully understand NR5A1's regulatory network and functions.