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The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch

Agnieszka T Kawashima1,2, Cassandra Wong3, Gema Lordén1

  • 1Department of Pharmacology, University of California, San Diego, California, USA.

Molecular and Cellular Biology
|January 5, 2021
PubMed
Summary

PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) is regulated during mitosis. Its phosphorylation controls binding to mitotic proteins, ensuring accurate cell division and supporting its tumor suppressor role.

Keywords:
Cdk1PHLPPmitosisphosphatase

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