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Related Concept Videos

Magnetic Flux01:18

Magnetic Flux

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The magnetic flux measures the number of magnetic field lines passing through a given surface area. The SI unit for magnetic flux is the weber (Wb). Magnetic flux is a scalar quantity. It depends on three factors: the strength of the magnetic field B, the area through which the field lines pass, and the relative orientation of the field with the surface area.
Suppose a surface is divided into elements of area dA. For each element, the component of the magnetic field that is normal to the...
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Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples
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Cellular autofluorescence is magnetic field sensitive.

Noboru Ikeya1, Jonathan R Woodward2

  • 1Graduate School of Arts and Sciences, The University of Tokyo, 153-8902, Tokyo, Japan.

Proceedings of the National Academy of Sciences of the United States of America
|January 5, 2021
PubMed
Summary
This summary is machine-generated.

Endogenous autofluorescence in HeLa cells responds to weak magnetic fields. This magnetic field sensitivity is explained by radical pair mechanisms involving flavins, impacting photoinduced electron transfer reactions.

Keywords:
autofluorescenceflavinsmagnetic field effectquantum biologyradical pair mechanism

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Area of Science:

  • Biophysics
  • Cell Biology
  • Quantum Biology

Background:

  • Cellular autofluorescence provides insights into metabolic processes.
  • Endogenous molecules like flavins are known to be sensitive to magnetic fields.
  • The radical pair mechanism is a quantum mechanical effect influencing chemical reactions.

Purpose of the Study:

  • To investigate the effect of weak magnetic fields on endogenous autofluorescence in HeLa cells.
  • To elucidate the underlying mechanism of magnetic field sensitivity in cellular autofluorescence.
  • To quantify the magnetic field dependence of these cellular responses.

Main Methods:

  • Direct, single-cell imaging kinetic measurements.
  • Spectroscopic analysis of autofluorescence.
  • Application of external magnetic fields up to 25 mT.

Main Results:

  • HeLa cell autofluorescence demonstrated sensitivity to magnetic fields as low as 25 mT.
  • Spectroscopic and mechanistic evidence pointed to magnetic field effects on flavin-based photoinduced electron transfer.
  • The observed magnetic field dependence aligned with a triplet-born radical pair mechanism, yielding a B1/2 of 18.0 mT and 3.7% saturation.

Conclusions:

  • Endogenous autofluorescence in HeLa cells is a measurable reporter for weak magnetic field effects.
  • The radical pair mechanism involving flavins is a key factor in cellular magnetic field sensitivity.
  • These findings open avenues for exploring quantum effects in biological systems.