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Level of Serum Vitamin D, To Which People Are at Risk of Developing Acute Myocardial Infarction in Bangladesh
K Akter1, I Khalilullah, S N Saqueeb
1Dr Khaleda Akter, Specialist, Laboratory Diagnostic Services, Ibrahim Cardiac Hospital & Research Institute (ICH&RI), Dhaka, Bangladesh;
Insights
Low vitamin D levels are linked to a higher risk of myocardial infarction (MI). This study found significantly lower serum vitamin D in patients with ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) compared to controls.
Area of Science:
- Cardiology
- Endocrinology
- Public Health
Background:
- Myocardial infarction (MI) incidence is rising in developing nations, often linked to coronary atherosclerosis.
- Vitamin D deficiency is increasingly recognized as a potential risk factor for atherosclerosis development.
Purpose of the Study:
- To investigate the association between serum vitamin D levels and acute myocardial infarction.
- To determine if vitamin D deficiency is an independent risk factor for MI.
Main Methods:
- A case-control study design was employed.
- Subjects were divided into three groups: STEMI, NSTEMI, and a control group of individuals without acute MI.
- Serum vitamin D levels were measured and compared across the groups.
Main Results:
- Mean serum vitamin D levels were significantly lower in STEMI (20.17 ng/ml) and NSTEMI (20.8 ng/ml) groups compared to the control group (24.77 ng/ml) (p<0.001).
- A statistically significant difference in vitamin D levels was observed among the three groups (p<0.001).
- Individuals with serum vitamin D <20 ng/ml demonstrated a higher likelihood of developing acute MI.
Conclusions:
- Low serum vitamin D is an independent risk factor for acute myocardial infarction.
- Maintaining adequate vitamin D levels may be crucial for preventing MI, particularly in at-risk populations.
Abstract:
Incidence of Myocardial Infarction is increasing day by day in developing countries. Most of the patients who sustain myocardial infarction have coronary atherosclerosis. There are several risk factors for the development of atherosclerosis. Among all the risk factors, vitamin D deficiency has been proposed to play an important role in the development of atherosclerosis. With this aim, a case-control study was carried out to explore the association of serum vitamin D with acute myocardial infarction. The enrolled study subjects were categorized into Group A which comprised of STEMI, Group B, comprised of NSTEMI and Group C comprised of age and sex matched individuals free from acute myocardial infarction. The mean values of serum vitamin D (in ng/ml) were 20.17, 20.8 and 24.77 respectively in STEMI, NSTEMI and control groups. It differed significantly among groups (p<0.001) and it was significantly low in STEMI and NSTEMI groups compared to control group (p<0.001 and p=0.004). From this study it can be concluded that low serum vitamin D is an independent risk factor for developing acute myocardial infarction. Individuals with serum vitamin D <20ng/ml have higher chance of developing acute myocardial infarction compared to those with serum vitamin D >20ng/ml.
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