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Related Experiment Video

Updated: Nov 23, 2025

Immunohistochemical Staining of B7-H1 PD-L1 on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue

Immunohistochemical Staining of B7-H1 PD-L1 on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue

Published on: January 3, 2013

PD-L1 expression in sebaceous carcinomas.

Maelle Saliba¹, Muhammad Shaheen¹, Rana El Hajj¹

¹Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Cairo Street, Beirut, Lebanon.

Cancer Immunology, Immunotherapy : CII

|January 5, 2021

Summary

Sebaceous carcinoma (SC) often resists traditional treatments. This study found PD-L1 expression in many SCs, suggesting potential for immune checkpoint inhibitors, especially in extraocular cases.

Keywords:

Human papilloma virus Immunotherapy PD-L1 Sebaceous carcinoma

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Immunohistochemical Staining of B7-H1 PD-L1 on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue

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Published on: January 3, 2013

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Published on: May 29, 2017

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients

Published on: September 25, 2018

Area of Science:

Oncology
Immunology
Dermatopathology

Background:

Traditional systemic treatments for advanced sebaceous carcinoma (SC) demonstrate limited efficacy.
Characterizing the tumoral immune microenvironment is crucial for evaluating immune checkpoint inhibitors (ICIs) in SC treatment.

Purpose of the Study:

To investigate the expression of programmed death-ligand 1 (PD-L1) and CD8+ T-cells in sebaceous carcinoma.
To assess the correlation between PD-L1 expression, CD8+ T-cell infiltration, and clinicopathologic features, including Human Papilloma Virus (HPV) status.
To determine the potential of PD-L1-targeted immunotherapies for SC treatment.

Main Methods:

Retrospective analysis of 173 resected sebaceous carcinoma (SC) cases.
Immunohistochemical assessment of PD-L1 expression on tumor cells (PD-L1+Tu) and immune infiltrates (PD-L1+Inf), and CD8+ T-cell density.
Calculation of combined positive scores (CPS) for PD-L1, correlating with lesion size, location, age, gender, and HPV status.

Main Results:

A therapeutically relevant combined positive score (CPS) for PD-L1 was observed in 51.4% of cases.
Higher PD-L1 expression and CPS were associated with larger lesion size and extraocular location.
Increased CD8+ T-lymphocyte density correlated significantly with higher PD-L1 expression and CPS, with infiltrates denser at the tumor periphery. HPV was detected in 8.4% of cases without significant association with PD-L1 or CPS.
Significant PD-L1 expression was noted, but with higher heterogeneity in extraocular versus periocular SCs.

Conclusions:

A substantial proportion of sebaceous carcinomas express PD-L1 at levels potentially responsive to immunotherapy.
The findings support further investigation into anti-PD-L1 immunotherapies, particularly for extraocular SC.
Prospective studies are warranted to evaluate the efficacy of PD-L1-targeted treatments in specific SC subtypes.