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Related Experiment Video

Updated: Nov 23, 2025

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
07:52

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Fiberless Optogenetics.

Srikanta Chowdhury1,2, Akihiro Yamanaka3,4,5

  • 1Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong, Bangladesh.

Advances in Experimental Medicine and Biology
|January 5, 2021
PubMed
Summary

Fiberless optogenetics uses special particles and near-infrared light to control neural activity without invasive implants. This minimally invasive technique overcomes limitations of traditional optogenetics for neuroscience research.

Keywords:
Fiberless optogeneticsLanthanidesNear-infrared lightOpsinsUp-conversion

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Last Updated: Nov 23, 2025

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Area of Science:

  • Neuroscience
  • Biotechnology
  • Biomedical Engineering

Background:

  • Optogenetics, using light to control cells, has revolutionized neuroscience.
  • Traditional optogenetics requires invasive optical fibers for light delivery.
  • Visible light used in optogenetics poorly penetrates biological tissues, limiting applications.

Purpose of the Study:

  • To introduce and discuss fiberless optogenetics as a minimally invasive alternative.
  • To address the limitations of traditional fiber-based optogenetics.
  • To highlight the potential of fiberless optogenetics for long-term neural control in freely behaving animals.

Main Methods:

  • Development of "fiberless optogenetics" using up-conversion luminescence particles.
  • Utilizing tissue-penetrating near-infrared light to activate particles.
  • Integration with other neuroscience tools like electrophysiology and behavioral analysis.

Main Results:

  • Fiberless optogenetics enables neural manipulation without implanting optical fibers.
  • Overcomes limitations of light penetration and tissue damage associated with traditional methods.
  • Allows for neural control over extended periods in freely moving subjects.

Conclusions:

  • Fiberless optogenetics represents a significant advancement in neural manipulation techniques.
  • This approach minimizes invasiveness and enhances applicability in neuroscience research.
  • Future applications extend beyond neuroscience, leveraging its unique advantages.