Related Experiment Video
Updated: Nov 23, 2025
Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
Published on: September 1, 2019
Emerging role of RNF2 in cancer: From bench to bedside
Qi Yan1, Bang-Jie Chen2, Shuang Hu3
1School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Abstract:
RNF2 (also known as ding, Ring1B or Ring2) is a member of the Ring finger protein family, which functions as E3 ubiquitin ligase for monoubiquitination of histone H2A at lysine 119 (H2AK119ub). RNF2 gene is located at the 1q25.3 site of human chromosome and the coding region is composed of 9 exons, encoding 336 amino acids in total. Many studies have demonstrated that overexpressed RNF2 was involved in the pathological progression of multiple cancers and has an impact on their clinical features. For instance, the upregulated expression level of RNF2 is positively correlated with the occurrence and progression of hepatocellular carcinoma, melanoma, prostate cancer, breast cancer, pancreatic cancer, gastric cancer, and bladder urothelial carcinoma, as well as with the radioresistance of lung cancer and chemoresistance of ovarian cancer. This review provides an up-to-date perspective on the relationship between RNF2 and several cancers and highlights recent studies on RNF2 regulation. In particular, the relevant cellular signaling pathways and potential clinical value of RNF2 in cancers are also discussed, suggesting its potential as an epigenetic biomarker and therapeutic target for these cancers.
Insights
Ring finger protein 2 (RNF2) acts as an E3 ubiquitin ligase and is implicated in various cancers. Overexpressed RNF2 correlates with cancer progression and resistance, suggesting its potential as a therapeutic target.
Area of Science:
- Epigenetics and Cancer Biology
- Molecular Oncology
- Biochemistry
Background:
- RNF2 (Ring finger protein 2) is an E3 ubiquitin ligase catalyzing histone H2A monoubiquitination (H2AK119ub).
- The RNF2 gene is located on human chromosome 1q25.3, with its coding region spanning 9 exons and encoding 336 amino acids.
Purpose of the Study:
- To review the association between RNF2 and various cancers.
- To highlight recent RNF2 regulation studies and its role in cancer progression.
- To discuss RNF2's involvement in cellular signaling pathways and its clinical potential.
Main Methods:
- Literature review of studies on RNF2 and cancer.
- Analysis of RNF2 expression levels in different cancer types.
- Examination of RNF2's role in epigenetic modifications and cellular signaling.
Main Results:
- Upregulated RNF2 expression is linked to the progression of hepatocellular carcinoma, melanoma, prostate, breast, pancreatic, gastric, and bladder cancers.
- Elevated RNF2 levels are associated with radioresistance in lung cancer and chemoresistance in ovarian cancer.
- RNF2's role in epigenetic regulation and its impact on cancer cell behavior are evident across multiple studies.
Conclusions:
- RNF2 is a significant factor in the pathological progression and clinical features of numerous cancers.
- RNF2 demonstrates potential as an epigenetic biomarker for cancer detection and prognosis.
- Targeting RNF2 presents a promising therapeutic strategy for various cancer types.
Related Concept Videos
02:26NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:03Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
02:53Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
02:23Abnormal Proliferation