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Spatiotemporal Characterization of GPCR Activity and Function during Endosomal Trafficking Pathway

Hyunbin Kim1,2, Hae Nim Lee1,3, Jaesik Choi4

  • 1Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.

Analytical Chemistry
|January 5, 2021
PubMed
Summary

Internalized G protein-coupled receptors (GPCRs), like beta-2 adrenergic receptor (B2AR), remain active for hours within endosomes, continuing to signal. This sustained activity impacts cellular functions and can be tracked using novel biosensors and kinetic models.

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