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Updated: Nov 22, 2025

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches
Published on: June 21, 2022
From Biophysical to Integrate-and-Fire Modeling
Tomas Van Pottelbergh1, Guillaume Drion2, Rodolphe Sepulchre3
1Department of Engineering, University of Cambridge, Cambridge CB2 1PZ, U.K. tmjv2@cam.ac.uk.
Abstract:
This article proposes a methodology to extract a low-dimensional integrate-and-fire model from an arbitrarily detailed single-compartment biophysical model. The method aims at relating the modulation of maximal conductance parameters in the biophysical model to the modulation of parameters in the proposed integrate-and-fire model. The approach is illustrated on two well-documented examples of cellular neuromodulation: the transition between type I and type II excitability and the transition between spiking and bursting.
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