Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

COPD: Pathogenesis and Clinical Features

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

Stages of Infection

Stages of Infection

Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

HIV-2 infection in Europe - persistence by migrant flows from West Africa but low spillover into the native population.

Le infezioni in medicina·2026

Same author

Disseminated paracoccidioidomycosis in a migrant from Paraguay.

Journal of travel medicine·2025

Same author

The cascade of care for hepatitis B - any lessons from the HIV field?

Expert review of anti-infective therapy·2025

Same author

Monkeypox 2024 outbreak.

AIDS reviews·2024

Same author

Strengthen the doctor-patient relationship and avoid administrative stifling.

AIDS reviews·2024

Same author

The new face of advanced HIV infection.

AIDS reviews·2024

Search research articles

Related Experiment Video

Updated: Nov 22, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

Unveiling Long COVID-19 Disease.

Vicente Soriano¹, Pilar Ganado-Pinilla¹, Miguel Sánchez-Santos¹

¹UNIR Medical Center and Health Sciences School, Madrid, Spain.

|January 5, 2021

Summary

Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2) does not cause chronic cellular infections. Unlike HIV or Hepatitis B virus, SARS-CoV-2 does not integrate its genome into host cells for long-term persistence.

More Related Videos

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

Related Experiment Videos

Last Updated: Nov 22, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

Area of Science:

Virology
Infectious Diseases
Cellular Biology

Background:

The clinical presentation of Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2) infections is broader than initially recognized.
Understanding the viral lifecycle and persistence mechanisms is crucial for managing infectious diseases.

Purpose of the Study:

To elucidate the cellular infection dynamics of SARS-CoV-2.
To compare the persistence strategies of SARS-CoV-2 with other known chronic viral infections like HIV and Hepatitis B virus.

Main Methods:

Comparative analysis of viral genome behavior within host cells.
Review of existing literature on SARS-CoV-2, HIV, and Hepatitis B virus cellular tropism and persistence.

Main Results:

SARS-CoV-2 does not establish a chronic cellular infection.
Unlike HIV (integrated provirus) and Hepatitis B virus (episomal genome), SARS-CoV-2 does not maintain its genetic material within host cells long-term.

Conclusions:

SARS-CoV-2 exhibits a different cellular infection pattern compared to viruses establishing chronic infections.
The transient nature of SARS-CoV-2 cellular infection has implications for understanding disease pathogenesis and treatment strategies.