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Updated: Jul 15, 2025
11:14
Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
Published on: November 7, 2018
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Triple Threat: HDV, HBV, HIV Coinfection
Debra W Yen1, Vicente Soriano2, Pablo Barreiro3
1Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Clinics in Liver Disease
|October 1, 2023
Summary
Hepatitis delta virus (HDV) is often missed in people with HIV and hepatitis B virus (HBV) coinfection, despite causing severe liver disease. Early recognition and novel treatments are crucial for this vulnerable population.
Area of Science:
- Hepatology
- Virology
- Infectious Diseases
Background:
- Hepatitis delta virus (HDV) requires hepatitis B virus (HBV) for its replication and assembly.
- HDV coinfection occurs in an estimated 15% of individuals with HIV and HBV due to shared transmission routes.
Purpose of the Study:
- To highlight the underdiagnosis of HDV in people living with HIV (PLWH) on antiretroviral therapy (ART) with suppressed HBV.
- To emphasize the severe liver disease progression associated with HDV and the need for increased recognition and treatment.
Main Methods:
- This study is a review of the literature concerning HDV, HBV, and HIV coinfection.
- Analysis of diagnostic challenges and treatment implications in PLWH.
Main Results:
- HDV coinfection is frequently underdiagnosed in PLWH, particularly those on ART with suppressed HBV.
- HDV infection leads to more severe chronic hepatitis, faster liver disease progression, and increased risk of hepatocellular carcinoma.
Conclusions:
- Increased awareness and diagnostic efforts for HDV are essential in PLWH with HBV.
- Further research into the efficacy of novel HDV treatments in PLWH is warranted as new therapies become available.
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