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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Cystatin C, Vitamin D and Thyroid Function Test Profile in Chronic Kidney Disease Patients

Marlene Tapper1, Donovan A McGrowder1, Lowell Dilworth1

  • 1Department of Pathology, Faculty of Medical Sciences, The University of the West Indies, Kingston 7, Jamaica.

Diseases (Basel, Switzerland)
|January 6, 2021
PubMed

Insights

Chronic kidney disease (CKD) patients frequently experience vitamin D deficiency and thyroid dysfunction, with severity increasing with disease progression. Elevated serum cystatin C indicates worsening CKD and associated complications.

Area of Science:

  • Nephrology
  • Endocrinology
  • Clinical Biochemistry

Background:

  • Chronic kidney disease (CKD) is linked to complications like thyroid dysfunction, dyslipidemia, and cardiovascular disease.
  • Assessing vitamin D status and thyroid function is crucial in CKD management.

Purpose of the Study:

  • To determine serum cystatin C levels in CKD patients.
  • To investigate the prevalence of vitamin D deficiency and thyroid dysfunction in CKD patients.

Main Methods:

  • A cross-sectional study included 140 CKD patients (stages 1-5).
  • Measurements included serum cystatin C, 25-OH-vitamin D, and thyroid function tests.
  • Data were analyzed using the cobas 6000 analyzer.

Main Results:

  • 92.1% of CKD patients had elevated serum cystatin C, increasing with CKD stage.
  • Hypothyroidism (overt and subclinical) was found in 10 patients.
  • Vitamin D deficiency or insufficiency was present in 44.2% of patients, worsening with CKD stage.

Conclusions:

  • Vitamin D deficiency and thyroid disorders are common in CKD patients.
  • These conditions worsen with advancing CKD, indicated by rising cystatin C levels.
  • Routine screening and intervention are recommended to mitigate cardiovascular risks.
Abstract

Keywords:
chroniccystatin Cdeficiencydiseaseinsufficiencykidneyprevalencethyroidvitamin D

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