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Biologically Active Compounds from Hops and Prospects for Their Use.

Marcel Karabín1, Tereza Hudcová1, Lukáš Jelínek1

  • 1Dept. of Biotechnology, Faculty of Food and Biochemical Technology, Univ. of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic.

Comprehensive Reviews in Food Science and Food Safety
|January 6, 2021
PubMed
Summary

Hops (Humulus lupulus) offer significant health benefits beyond beer flavoring. Their compounds, including prenylflavonoids and bitter acids, show antioxidant, anti-inflammatory, and neuropharmacological properties, potentially aiding in disease prevention.

Keywords:
biologically active compoundsbitter acidsessential oilshopspolyphenols

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Area of Science:

  • Phytochemistry
  • Pharmacology
  • Ethnobotany

Background:

  • Hop cones (Humulus lupulus) are traditionally used in folk medicine.
  • Known primarily for beer flavoring, hops possess significant health-promoting properties.
  • The study reviews scientific knowledge on hop's secondary metabolites.

Purpose of the Study:

  • To summarize the pharmacological effects of hop's major secondary metabolites.
  • To highlight the potential of hop compounds in the pharmaceutical industry.
  • To explore the health benefits of moderate beer consumption.

Main Methods:

  • Literature review of scientific knowledge on hop secondary metabolites.
  • Analysis of pharmacological properties of polyphenols, essential oils, and resins.
  • Focus on prenylflavonoids, alpha bitter acids, and their effects.

Main Results:

  • Hop compounds exhibit antioxidant, anti-inflammatory, and anticancer properties.
  • Prenylflavonoids are potent phytoestrogens found almost exclusively in hops.
  • Hop oils and resins possess sedative, neuropharmacological, antibacterial, and antifungal effects.
  • Alpha bitter acids show potential in preventing metabolic syndrome-related diseases.

Conclusions:

  • Hops contain diverse compounds with significant pharmacological potential.
  • Prenylflavonoids and alpha bitter acids are key bioactive constituents.
  • Hops represent a valuable natural resource for pharmaceutical development and health promotion.