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Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships
Kong Zhang1, Tianze Li1, Xijie Shan1
1College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, China.
Mini Reviews in Medicinal Chemistry
|January 6, 2021
Summary
This review summarizes structural modifications of cholesterol and its derivatives from 2014-2020. It explores their diverse bioactivities, mechanisms, and structure-activity relationships for anticancer and anti-inflammatory applications.
Area of Science:
- Biochemistry
- Medicinal Chemistry
Background:
- Cholesterol, a steroid alcohol discovered in 1815, possesses diverse biological properties.
- Derivatives of cholesterol exhibit significant anticancer, anti-inflammatory, antimicrobial, and antioxidant activities.
Purpose of the Study:
- To summarize advances in cholesterol structural modification between 2014 and 2020.
- To discuss the bioactivities, mechanisms of action, and structure-activity relationships of cholesterol derivatives.
Main Methods:
- Literature review of scientific publications from 2014 to 2020.
- Analysis of structural modifications and reported bioactivities of cholesterol derivatives.
Main Results:
- Recent structural modifications have enhanced the therapeutic potential of cholesterol derivatives.
- Established structure-activity relationships provide insights into optimizing bioactivity.
Conclusions:
- Cholesterol derivatives represent a promising scaffold for developing novel therapeutic agents.
- Further research into cholesterol modification can yield compounds with improved anticancer and anti-inflammatory properties.
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