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Roles of miRNA dysregulation in the pathogenesis of multiple myeloma

Dan Chen1, Xinhong Yang2, Min Liu2

  • 1Department of Central Laboratory, The Affiliated Hospital of Chengde Medical College, Chengde, Hebei, China.

Cancer Gene Therapy
|January 6, 2021
PubMed

Insights

MicroRNAs (miRNAs) play a crucial role in multiple myeloma (MM) progression and drug resistance. Understanding these small RNAs offers potential for new prognostic biomarkers and therapeutic strategies against this incurable cancer.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Multiple myeloma (MM) is a complex plasma cell malignancy causing significant morbidity.
  • Novel agents have improved patient outcomes, but MM remains incurable with considerable heterogeneity.
  • MicroRNAs (miRNAs) are noncoding RNAs regulating gene expression and are implicated in MM pathology.

Purpose of the Study:

  • To summarize the current knowledge on the roles of miRNAs in multiple myeloma.
  • To highlight the significance of miRNAs in regulating MM progression factors.
  • To discuss the potential of miRNAs as prognostic biomarkers and therapeutic targets for MM.

Main Methods:

  • Literature review and synthesis of existing research on miRNAs in multiple myeloma.
  • Analysis of miRNA involvement in key pathological factors of MM.
  • Evaluation of miRNA potential in prognosis and therapy.

Main Results:

  • miRNA deregulation is closely linked to MM initiation, progression, metastasis, prognosis, and drug response.
  • miRNAs significantly regulate critical pathological factors in MM, including the bone marrow microenvironment, methylation, immune regulation, genomic instability, and drug resistance.

Conclusions:

  • miRNAs are integral to the complex pathology of multiple myeloma.
  • Targeting the miRNA network presents a promising avenue for novel anti-MM therapeutic approaches.
  • miRNAs hold potential as valuable prognostic biomarkers and therapeutic targets for multiple myeloma.

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