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Presynaptic M1 muscarinic receptor modulates spontaneous release of acetylcholine from rat basal forebrain slices
T Suzuki1, K Fujimoto, H Oohata
1Department of Pharmacology, Kyoritsu College of Pharmacy, Tokyo, Japan.
Neuroscience Letters
|January 22, 1988
Abstract:
Spontaneous release of acetylcholine (ACh) from rat basal forebrain slices in the presence of cholinesterase inhibitor was directly determined using a specific radioimmunoassay for ACh. The release was calcium dependent. A consistent amount of ACh release was observed throughout the experiment. Atropine (10(-8) to 10(-5) M) and pirenzepine (10(-7) to 10(-5) M) enhanced spontaneous ACh release. These findings indicate the presence of an M1 muscarinic autoreceptor that modulates spontaneous release of ACh in the rat basal forebrain.