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Related Experiment Video

Updated: Nov 22, 2025

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
09:11

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Published on: April 9, 2019

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Visualized Prostate Biopsy: An Intuitive Three-Dimensional User Interface for Systematic and Targeted Biopsy.

Samsun Lampotang1,2,3,4, Thomas Stringer5, David Lizdas1,3

  • 1Center for Safety, Simulation and Advanced Learning Technologies, University of Florida College of Medicine, Gainesville, Florida, USA.

Journal of Endourology
|January 6, 2021
PubMed
Summary

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Visualized prostate biopsy (vPBx) uses a 3D interface to guide biopsies, significantly reducing false negatives. This innovative approach aims to improve prostate cancer detection accuracy during procedures.

Area of Science:

  • Medical Imaging
  • Surgical Technology
  • Urology

Background:

  • Prostate biopsy has high false-negative rates (21-47% for systematic, 16-30% for fused methods).
  • Current biopsy guidance lacks real-time feedback, potentially missing lesions.
  • Need for improved accuracy in prostate cancer diagnosis.

Purpose of the Study:

  • To evaluate the effectiveness of a visualized prostate biopsy (vPBx) system.
  • To determine if a 3D interface can reduce false-negative rates in simulated prostate biopsies.
  • To assess user performance with vPBx compared to traditional transrectal ultrasound (TRUS) guidance.

Main Methods:

  • Developed a 3D environment tracking the prostate, ultrasound probe, and biopsy device.
  • Utilized a simulator with simulated TRUS for 48 participants performing systematic biopsy.
Keywords:
biopsyfalse negativesprostate cancerthree-dimensional observation

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  • Compared traditional TRUS guidance with the novel visualized prostate biopsy (vPBx) system.

    • Main Results:

    • Visualized prostate biopsy (vPBx) reduced the false-negative rate for a simulated apical lesion from 52% to 2% (p < 0.001).
    • Participants performed systematic biopsy with both traditional TRUS and vPBx guidance.
    • The 3D interface provided real-time guidance and feedback during simulated procedures.

    Conclusions:

    • Visualized prostate biopsy (vPBx) shows significant potential to decrease false-negative rates.
    • Preliminary simulated results support retrofitting vPBx to actual TRUS equipment.
    • Further clinical trials are warranted to validate vPBx in patient procedures.