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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Related Experiment Video

Updated: Nov 22, 2025

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Biodegradable Defined Shaped Printed Polymer Microcapsules for Drug Delivery.

Valeriya Kudryavtseva1,2, Stefania Boi3, Jordan Read4

  • 1Nanoforce Technology Ltd, School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, United Kingdom.

ACS Applied Materials & Interfaces
|January 6, 2021
PubMed
Summary

Researchers developed printed biodegradable polymer capsules for drug delivery. These polylactic acid capsules, in pyramid and rectangular shapes, show potential for intracellular delivery without toxicity.

Keywords:
drug deliverymicroprintingpolylactic acidpolymer capsulessoft lithography

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Biodegradable polymers are crucial for developing advanced drug delivery systems.
  • Controlling capsule morphology and size is key for efficient cellular uptake and cargo release.

Purpose of the Study:

  • To prepare and characterize printed biodegradable polymer capsules (polylactic acid) in distinct shapes (pyramid, rectangular).
  • To evaluate their potential for encapsulating and releasing water-soluble molecules for intracellular delivery.

Main Methods:

  • Fabrication of core-shell capsules using 3D printing techniques.
  • Characterization of capsule morphology, size distribution, loading efficiency, and cargo release profiles.
  • Assessment of cell cytotoxicity and cellular uptake using HeLa cells.

Main Results:

  • Successfully produced monodisperse pyramid and rectangular polylactic acid capsules (1 and 11 microm).
  • Demonstrated stability for encapsulating and retaining small water-soluble molecules for several days.
  • Confirmed intracellular delivery capability and lack of toxicity in HeLa cells for 1-microm capsules.

Conclusions:

  • Printed biodegradable polymer capsules offer a versatile platform for drug delivery.
  • Controllable shape and size, along with triggered release, present unique advantages over existing systems.
  • These capsules show significant promise for targeted intracellular delivery applications.