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Updated: Nov 22, 2025
Porcine Model of Infrarenal Abdominal Aortic Aneurysm
Published on: November 21, 2019
A new porcine model of ascending aortic aneurysm established using a cover-then-cut method
Zhenjiang Li1,2, Junjun Liu1,3, Rui Feng1
1Department of Vascular Surgery, Changhai Hospital, Navy Medical University, 168 Changhai Road, Shanghai, 200433, China.
Purpose:
To establish a reproducible porcine model of ascending aortic aneurysm (AsAA).
Methods:
We created an AsAA in twelve domestic pigs using a cover-then-cut method, stitching a glutaraldehyde tanned bovine pericardial patch onto the anterolateral aortic wall, then cutting off aortic wall tissue within the patch, and closing the incision in the patch.
Results:
The AsAA creation was completed successfully in 11 out of the 12 pigs (91.7%). The mean maximal diameter of the ascending aorta increased significantly by 1.77 times, immediately after the operation (p < 0.05). Significantly continuous expansion of the aneurysm was observed during the follow up period, to 48.9 ± 1.80 mm at 3 months and 50.3 ± 2.25 mm at 6 months (p < 0.05).
Conclusions:
This porcine model of AsAA, created using a repeatable cover-then-cut method, represents a reproducible platform for studying and training, which could contribute to the development of new feasible endovascular treatments of AsAAs.
