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Leishmaniasis and Trace Element Alterations: a Systematic Review.

Ali Taghipour1, Amir Abdoli2,3, Afifeh Ramezani4

  • 1Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Biological Trace Element Research
|January 6, 2021
PubMed
Summary
This summary is machine-generated.

Trace element alterations are common in leishmaniasis patients. Selenium, zinc, and iron levels decrease, while copper and magnesium increase, suggesting their role in disease prognosis and potential as adjuvant therapies.

Keywords:
CopperIronLeishmaniasisMagnesiumSeleniumTrace elementsZinc

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Area of Science:

  • Parasitology
  • Immunology
  • Nutritional Science

Background:

  • Leishmaniasis, a widespread parasitic disease, presents in visceral (VL), cutaneous (CL), and mucocutaneous (MCL) forms.
  • Current treatment options for leishmaniasis are limited, and no human vaccine is available.
  • Alterations in trace elements (TEs) like selenium (Se), zinc (Zn), copper (Cu), iron (Fe), and magnesium (Mg) are observed in leishmaniasis patients.

Purpose of the Study:

  • To systematically review data on trace element alterations in human and animal leishmaniasis.
  • To explore the potential role of trace elements as adjuvant therapy for leishmaniasis.

Main Methods:

  • A systematic review of 29 eligible articles published up to October 1, 2020.
  • Analysis of trace element levels in human CL, human VL, canine leishmaniasis, and leishmaniasis treatment studies.

Main Results:

  • Significantly decreased levels of Fe, Zn, and Se were found in human CL and canine leishmaniasis.
  • Zn and Fe levels were decreased in VL patients, while Cu levels increased in CL and VL patients.
  • Mg levels were elevated in VL patients and canine leishmaniasis.
  • Zinc supplementation in CL treatment enhanced wound healing and reduced scarring.

Conclusions:

  • Trace elements play a significant role in leishmaniasis and can serve as prognostic factors.
  • Trace elements show potential as adjuvant therapies for both cutaneous and visceral leishmaniasis.