Engineering Lignin Stabilized Bimetallic Nanocomplexes: Structure, Mechanistic Elucidation, Antioxidant, and
Sanjam Chandna1, Neeraj Singh Thakur1, Yeddula Nikhileshwar Reddy1
1Department of Nanomaterials and Application Technology, Center of Innovative and Applied Bioprocessing (CIAB), Sector 81 (Knowledge City), S.A.S. Nagar, Punjab 140306, India.
ACS Biomaterials Science & Engineering
|January 6, 2021
Summary
This study synthesizes novel silver-gold nanocomplexes using lignin, a biopolymer from agro-waste. These lignin-stabilized nanoagents exhibit enhanced antioxidant and antimicrobial properties, offering a sustainable route to functional nanomaterials.
Area of Science:
- Materials Science
- Biotechnology
- Nanotechnology
Background:
- Lignin, a biopolymer from agro-waste, possesses inherent antioxidant and antimicrobial properties.
- Underutilized biopolymers like lignin present opportunities for developing value-added nanomaterials.
- Developing novel nanoagents with synergistic properties is crucial for various applications.
Purpose of the Study:
- To synthesize silver-gold bimetallic and monometallic nanocomplexes using lignin as a matrix.
- To investigate the synergistic antioxidant and antimicrobial activities of lignin-stabilized nanoagents.
- To explore the potential of waste-derived lignin in creating functional nanomaterials.
Main Methods:
- One-pot synthesis of nanocomplexes with lignin acting as reducing, capping, and stabilizing agent.
- Characterization of nanocomplexes using techniques like SEM and TEM.
- Evaluation of antioxidant activity via phenolic and flavonoid content, and antimicrobial activity through various mechanistic studies.
Main Results:
- Successful synthesis of lignin-stabilized silver-gold monometallic and bimetallic nanocomplexes.
- Demonstrated substantial phenolic and flavonoid content, correlating with high antioxidant activity.
- Elucidation of antimicrobial mechanisms, including reactive oxygen species generation and DNA cleavage, supported by live-dead cell imaging.
Conclusions:
- Lignin can effectively stabilize silver-gold nanoagents, creating functional nanomaterials with synergistic antioxidant and antimicrobial properties.
- The developed nanocomplexes show potential for waste valorization into high-value products.
- This research contributes to the development of sustainable nanomaterials for biomedical and other applications.
More Related Videos
Related Concept Videos
01:09Complexation Equilibria: Factors Influencing Stability of Complexes
639
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
639
02:51Metal-Ligand Bonds
22.9K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
22.9K
01:19Complexation Equilibria: The Chelate Effect
883
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
883