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Updated: Nov 22, 2025
Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
Tracking stem cells in the incisional hernial sac: a gaze beyond pure tissue repairs
Renato Miranda DE Melo1,2,3, Roberpaulo Anacleto Neves4, Liliana Borges DE Menezes5
1- Universidade Federal de Goiás, Faculdade de Medicina, Departamento de Cirurgia - Goiânia - GO - Brasil.
Objective:
the hernial sac is typically a bilayer structure consisting of connective tissue lined underneath by peritoneum. Some incidental findings on it, like smooth muscle cells and heterotopic ossification, can be explained as the end-stage metaplasia from undifferentiated cells. This study aimed to search for mesenchymal stem cells in the incisional hernial sac by an immuno-histochemistry screening test.
Methods:
fifteen specimens of them were submitted to histochemistry analysis using CD133 monoclonal antibodies, a specific marker of mesenchymal stem cells. The biopsies were obtained from patients submitted to pure tissue repair for incisional hernias - the transposition with the hernial sac technique (Lázaro da Silva, 1971).
Results:
two-thirds of the specimens expressed on average 20 (twenty) CD133+ cells in each one.
Conclusion:
despite the screening nature of this study, the hernial sac may be considered a source of stem cells. This could explain those abnormal findings, and perhaps the induction of new fibroblasts in procedures that use it to optimize wound healing.
