Uremic Sarcopenia and Its Possible Nutritional Approach.

Area of Science:

• Nephrology
• Geriatrics
• Nutritional Science

Background:

• Uremic sarcopenia is prevalent in chronic kidney disease (CKD) patients, characterized by decreased muscle mass, strength, and physical function.
• It significantly increases hospitalization risk and mortality in CKD patients.
• Contributing factors include aging, metabolic acidosis, hemodialysis, inflammation, and poor protein-energy intake.

Purpose of the Study:

• To review the benefits of nutritional therapy, alone or combined with physical activity, for uremic sarcopenia.
• To analyze the impact of these interventions on the onset and progression of uremic sarcopenia.

Main Methods:

• Literature review of studies on nutritional interventions for uremic sarcopenia.
• Analysis of physical activity programs in conjunction with nutritional support.
• Synthesis of evidence regarding the efficacy of combined therapeutic approaches.

Main Results:

• Nutritional therapies, including supplements and specialized diets, can mitigate muscle loss.
• Personalized physical activity programs enhance muscle strength and function.
• Combined nutritional and physical activity interventions demonstrate synergistic effects in managing uremic sarcopenia.

Conclusions:

• Nutritional therapy is a cornerstone in managing uremic sarcopenia.
• Integrating physical activity with nutritional support offers a comprehensive strategy.
• Further research is warranted to optimize combined interventions for CKD patients.