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The association between retinal vessel abnormalities and H-type hypertension
Kuankuan Huang1, Zhixiang Zhang1, Shan Huang1
1Department of Neurology, Changzhou No.2 People's Hospital Affiliated to Nanjing Medical University, No.29, Xinglong Lane, Tianning District, Changzhou, 213004, Jiangsu, China.
BMC Neurology
|January 7, 2021
Summary
H-type hypertension is linked to more retinal abnormalities than isolated hypertension. Managing H-type hypertension may lower the risk of small blood vessel damage in the eyes.
Area of Science:
- Ophthalmology
- Cardiology
- Hypertension Research
Background:
- H-type hypertension, characterized by elevated plasma homocysteine (HCY), is a distinct hypertensive subtype.
- Retinal vessel abnormalities are potential indicators of systemic vascular damage.
Purpose of the Study:
- To investigate the association between H-type hypertension and retinal vessel abnormalities.
- To compare the prevalence and severity of retinal changes in patients with H-type hypertension versus isolated hypertension.
Main Methods:
- Retrospective analysis of 191 hypertensive patients, categorized by plasma HCY levels.
- Evaluation of retinal fundus photography for vessel diameter (CRAE, AVR) and retinopathy.
- Univariate and multivariate regression analyses to identify risk factors for retinal abnormalities.
Main Results:
- H-type hypertension group showed a higher ratio of retinopathy and more severe retinal arteriosclerosis.
- Patients with H-type hypertension had significantly smaller central retinal artery equivalents (CRAE) and arteriovenous ratios (AVR).
- Multivariate analysis confirmed H-type hypertension as an independent risk factor for retinopathy, CRAE, and AVR.
Conclusions:
- H-type hypertension is significantly associated with increased retinal vessel abnormalities compared to isolated hypertension.
- Controlling H-type hypertension may be crucial in preventing or mitigating microvascular damage in the retina.
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