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Published on: June 21, 2019
Enhanced gamma band mutual information is associated with impaired consciousness during temporal lobe seizures
Puneet Dheer1, Sandipan Pati2, Kalyan Kumar Chowdhury3
1Systems Science and Informatics Unit, Indian Statistical Institute, 8th Mile, Mysore Road, Bangalore, India, 560059.
Background:
Epileptic seizures are characterized by aberrant synchronization. We hypothesized that higher synchronization across the seizure onset zone (SOZ) channels during a temporal lobe seizure contributes to impaired consciousness.
New Method:
All symmetric bivariate synchronization measures were extended to multivariate measure by a principal component analysis (PCA) based technique. A novel nonparametric method has been proposed to test the statistical significance between increased synchronization across the seizure onset zone (SOZ) channels and reduced consciousness.
Results:
Increased synchronization in the gamma band towards seizure termination significantly contributes to impaired consciousness (p < 0.1). Synchronization reaches its peak in the extratemporal region (frontal lobe) ahead of the temporal region (p < 0.05). Synchronization is prominent in beta and gamma bands by most methods and it is more in the second half of seizure duration than in the first (p < 0.05).
Conclusions:
Mutual information is the only synchronization measure out of the six that we studied, whose increase can be associated with the loss of consciousness in a statistically significant way.
