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Relation Between Zinc and Thyroid Hormones in Humans: a Systematic Review
Jéssica Batista Beserra1, Jennifer Beatriz Silva Morais1, Juliana Soares Severo1
1Department of Nutrition, Federal University of Piauí, Campus Minister Petrônio Portela, Teresina, Piauí, Brazil.
Biological Trace Element Research
|January 7, 2021
Summary
This systematic review found inconclusive evidence on zinc supplementation
Area of Science:
- Endocrinology
- Nutritional Science
Background:
- Thyroid hormones are crucial for metabolic regulation.
- Zinc plays a role in thyroid hormone synthesis and metabolism.
- Existing research on the zinc-thyroid axis is varied.
Purpose of the Study:
- To systematically evaluate the relationship between zinc and thyroid hormones in humans.
- To assess the impact of zinc supplementation on thyroid hormone levels.
Main Methods:
- Systematic review following PRISMA guidelines.
- Searched PubMed, Scopus, CENTRAL, and ScienceDirect databases.
- Assessed risk of bias using the Cochrane Collaboration tool.
Main Results:
- Included 8 studies on zinc supplementation and 10 on zinc concentration and thyroid hormones.
- Cross-sectional and case-control studies suggest a link between zinc deficiency and thyroid issues.
- Evidence on zinc supplementation's effect on thyroid hormones is inconclusive due to study heterogeneity and focus on diseased populations.
Conclusions:
- The current evidence is insufficient to generalize the effects of zinc supplementation on thyroid hormones to the general population.
- Further research is needed, focusing on diverse populations and standardized methodologies.
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