Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consensus on Subdomains and Measures of Relevance to Affective and Social Cognition Research on Bipolar Disorder (CAS-BD); Outcomes and Recommendations From an International Society for Bipolar Disorders Targeting Cognition Taskforce Study.

Bipolar disorders·2026
Same author

Hippocampal Function and Markers of Citrullinated Proteins and Bacterial and Viral Infection in Fibromyalgia.

Current rheumatology reviews·2026
Same author

Basophilic Response in Patients with Persistent Symptoms Attributed to Lyme Borreliosis Treated with Hydrolysed Arabinoxylan Rice Bran.

Medicina (Kaunas, Lithuania)·2025
Same author

An Integrated Treatment Approach for Bipolar II Disorder: A Clinical Case Study.

Journal of clinical medicine·2025
Same author

Babesiosis: Analysis of the Evidence for Infections in the United Kingdom.

International journal of general medicine·2024
Same author

Brief Coping Scale TCS-9: Optimising the Assessment of Coping Strategies. The case of Health Care Workers.

Health psychology research·2024

Related Experiment Video

Updated: Nov 22, 2025

A Protocol for the Administration of Real-Time fMRI Neurofeedback Training
07:05

A Protocol for the Administration of Real-Time fMRI Neurofeedback Training

Published on: August 24, 2017

11.3K

Increasing Nrf2 Activity as a Treatment Approach in Neuropsychiatry.

G Morris1, A J Walker1, K Walder1

  • 1Institute for Mental and Physical Health and Clinical Translation (IMPACT), Barwon Health, School of Medicine, Deakin University, Geelong, VIC, Australia.

Molecular Neurobiology
|January 7, 2021
PubMed
Summary
This summary is machine-generated.

Nuclear factor erythroid 2-related factor 2 (Nrf2) activation combats oxidative stress in neuropsychiatric disorders. Supplements like N-acetylcysteine, coenzyme Q10, and melatonin enhance Nrf2 activity, offering therapeutic potential.

Keywords:
Coenzyme Q10MelatoninMolecular neurobiologyN-acetylcysteineNrf2Oxidative stress

More Related Videos

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing
09:02

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

Published on: June 9, 2017

23.9K
Method for the Assessment of Effects of a Range of Wavelengths and Intensities of Red/near-infrared Light Therapy on Oxidative Stress In Vitro
08:16

Method for the Assessment of Effects of a Range of Wavelengths and Intensities of Red/near-infrared Light Therapy on Oxidative Stress In Vitro

Published on: March 21, 2015

9.0K

Related Experiment Videos

Last Updated: Nov 22, 2025

A Protocol for the Administration of Real-Time fMRI Neurofeedback Training
07:05

A Protocol for the Administration of Real-Time fMRI Neurofeedback Training

Published on: August 24, 2017

11.3K
Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing
09:02

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

Published on: June 9, 2017

23.9K
Method for the Assessment of Effects of a Range of Wavelengths and Intensities of Red/near-infrared Light Therapy on Oxidative Stress In Vitro
08:16

Method for the Assessment of Effects of a Range of Wavelengths and Intensities of Red/near-infrared Light Therapy on Oxidative Stress In Vitro

Published on: March 21, 2015

9.0K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating cellular antioxidant responses.
  • Neuropsychiatric disorders like depression, bipolar disorder, and schizophrenia are linked to chronic oxidative and nitrosative stress.
  • Elevated reactive oxygen species, nitric oxide, and peroxynitrite contribute to cellular damage in these conditions.

Purpose of the Study:

  • To explore the role of Nrf2 in the context of oxidative stress in neuropsychiatric illnesses.
  • To investigate the impact of N-acetylcysteine, coenzyme Q10, and melatonin on Nrf2 activity and cellular protection.

Main Methods:

  • Review of literature on Nrf2 pathway activation and its relation to oxidative stress markers.
  • Analysis of studies investigating the effects of N-acetylcysteine, coenzyme Q10, and melatonin on cellular and mitochondrial function.

Main Results:

  • Nrf2 upregulation increases cellular antioxidant defenses, including glutathione and thioredoxin systems.
  • Nrf2 activation is a proposed therapeutic target for neuropsychiatric disorders characterized by oxidative damage.
  • Supplementation with N-acetylcysteine, coenzyme Q10, and melatonin enhances Nrf2 activity and offers neuroprotective benefits.

Conclusions:

  • Nrf2 plays a critical role in cellular defense against oxidative stress relevant to neuropsychiatric disorders.
  • N-acetylcysteine, coenzyme Q10, and melatonin show promise as adjunctive therapies by boosting Nrf2-mediated antioxidant pathways.
  • Targeting Nrf2 offers a potential strategy to mitigate neuroinflammation and oxidative damage in neuropsychiatric conditions.