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Aptamer-functionalized metal-organic frameworks (MOFs) for biosensing.

Mengzhen Lv1, Wan Zhou2, Hamed Tavakoli2

  • 1College of Chemistry and Chemical Engineering, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, Qingdao University, Qingdao, 266071, PR China; Department of Chemistry and Biochemistry, University of Texas at El Paso, El Paso, 79968, USA.

Biosensors & Bioelectronics
|January 7, 2021
PubMed
Summary

Metal-organic frameworks (MOFs) functionalized with aptamers create high-performance biosensors. These aptasensors offer advanced applications in medical diagnostics, food safety, and environmental monitoring.

Keywords:
AptamerAptasensorBiosensorMetal-organic frameworks (MOFs)MicrofluidicStimuli-responsive

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Analytical Chemistry
  • Biotechnology

Background:

  • Metal-organic frameworks (MOFs) are crystalline porous materials with unique nanoscale structures, large surface areas, and tunable properties.
  • MOFs offer versatile applications in biosensing due to their stability and functionalizability.
  • Aptamer functionalization enhances MOFs for specific biomolecule detection.

Purpose of the Study:

  • To review recent innovations in aptamer-functionalized MOF-based biosensors.
  • To summarize the construction methods and applications of these advanced biosensing platforms.
  • To explore future trends, including stimuli-responsive materials and microfluidic integration.

Main Methods:

  • Review of functionalization strategies for combining MOFs and aptamers.
  • Categorization of MOF-based aptasensors based on detection mechanisms (optical, electrochemical, photoelectrochemical).
  • Discussion of MOFs as signal probes or carriers in sensing systems.

Main Results:

  • Aptamer-functionalized MOFs enable high-performance biosensing for diverse applications.
  • MOFs can act as signal probes or carriers, enhancing detection sensitivity and specificity.
  • Emerging applications include stimuli-responsive aptasensors and integration into microfluidic devices.

Conclusions:

  • Aptamer-functionalized MOFs represent a powerful platform for developing advanced biosensors.
  • Continued research in stimuli-responsive materials and microfluidics will expand their utility.
  • These biosensors hold significant promise for medical diagnostics, environmental monitoring, and food safety.