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Updated: Nov 22, 2025

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Measurement Methods to Detect, Characterize, and Quantify Engineered Nanomaterials in Foods
Gurmit Singh1, Chady Stephan2, Paul Westerhoff3
1Food Research Div, Bureau of Chemical Safety, Health Canada, 251 Sir Frederick Banting Driveway, Ottawa, Canada.
Detecting engineered nanomaterials (ENMs) in food requires addressing matrix interferences. This review analyzes methods for ENM detection in complex food matrices, identifying knowledge gaps.
Area of Science:
- Food Safety
- Nanotechnology
- Analytical Chemistry
Background:
- Engineered nanomaterials (ENMs) are increasingly used in food products.
- Assessing the safety of ENMs in food requires reliable detection and characterization methods.
- The NanoRelease Food Additive project aims to develop such methods.
Purpose of the Study:
- To review and analyze existing literature on detecting ENMs in food matrices.
- To identify challenges, particularly matrix interferences, in ENM detection.
- To summarize current and emerging analytical techniques for ENM detection in food.
Main Methods:
- Comprehensive literature review of ENM detection in complex food matrices.
- Analysis of sampling techniques, including centrifugation and extraction.
- Evaluation of available and emerging analytical methodologies.
Main Results:
- Matrix interferences are a significant challenge for ENM detection in food.
- Various sampling and extraction methods can mitigate matrix effects.
- A range of analytical techniques exist, with ongoing development of novel methods.
Conclusions:
- Accurate detection of ENMs in food is crucial for risk assessment.
- Further method development is needed to address remaining knowledge gaps.
- Standardized protocols for ENM detection in food matrices are essential.
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